1. Most common cancer worldwide is :
A. Breast Cancer
B. Bladder Cancer
C.Lung Cancer
D. Ovarian Cancer
EXPLANATION: Ans: C. Lung Cancer
Most common Cancer among males worldwide is Lung cancer.
Most common Cancer among females worldwide is Breast cancer
Most common Cancer among males Indias Oro-Pharyngeal cancer
Most common Cancer among females India is Breast cancer followed by Cervical Cancer.
2 Most common Lung Cancer in India is:
A. Small cell Cancer
B. Adeno Cancer
C. Squamous cell Cancer
D. Large cell Cancer
EXPLANATION: Ans: C. Squamous cell Cancer
Most common lung cancer worldwide is adenocarcinoma
Most common lung cancer in India (Asia): Squamous sell carcinoma
Most common lung CANCER in women in adenocarcinoma
Most common lung cancer in smokers is squamous cell carcinoma
Most common lung cancer in non smokers is adenocarcinoma
Most common lung cancer in young patients is adenocarcinoma
Most common lung cancer to metastasis is small cell carcinoma
3. Most common occupational malignancy in India is:
A. Breast
C. Skin
B. Lungs
D. Bladder
EXPLANATION: Ans C- Skin
occapational malignancy affects -
Skin 75% (Most Common).
Lungs
Bladder
Blood forming organs
4 Serum sickness is which type of hypersensivity reaction
A. I
B. II
C III
D. IV
EPLANATION: Ans: C. III
5. Hypersensitivity Pneumonitis is classically described as a?
A. Type I hypersensitivity reaction
B. Type Il hypersensitivity reaction
C. Type III (Immune complex) Hypersensitivity
D. Type IV (Cell mediated) Hypersensitivity
EXPLANATION: Ans: C. Type III (Immune complex) Hypersensitivity
"Hypersensitivity Pneumonitis is Type III immune complex) hypersensitivity
.6. The immunoglobulin involved in type l hypersensitivity reaction is:
A. IgE
B. IgM
D. IgG
C. IgA
EXPLANATION: Ans: A. IgE
*The immunoglobulin involved in type l hypersensitivity reaction is IgE
7. All are type II hypersensitivity reaction except:
A Steven Johnson's syndrome
B. Drug induced hemolytic anemia
C. Drug induced thrombocytopenia
D. Hemolytic disease of newborn
EXPLANATION: Ans: A. Steven Johnson's syndrome
"All blood related diseases comes under Hypersensitivity reaction type II, So Steven johson's Syndrome is best answer in given above options"
8. Kaposi Sarcoma caused by -
A. HSV 8
B. 'HIV-1
C. HIV II
D. HPV 8
EXPLANATION: Ans: A. HSV 8
Most common carcinoma in AIDS.
Caused by HHV-8
Arising form Blood vessels (Vascular Tumor)
HSV 8 - HERPES SIMPLEX VIRUS
HHV8 - HUMAN HERPES VIRUS
HPV 8 - HUMAN PAPILOMA VIRUS
9. Which of the following is X-linked dominant:
A. Duchenne's Muscular Dystrophy
B. G6PD deficiency
D.. Vit-D résistant rickets
C. Color blindness
EXPLANATION: Ans: D. Vit-D résistant rickets
# G6PD- glucose-6-phosphate dehydrogenase
10. Which of the following is NOT inherited as X-linked disease:
A. Hemophilia A
B. G6PD deficiency
C. Color blindness
D. cystic fibrosis
EXPLANATION: Ans: D. Cystic Fibrosis
Cystic fibrosis is an inherited as Autosomal Recessive
11. All of the following factor are affected by warfarin EXCEPT:
A. Factor II
B. Facto: IX
C. Factor VIII
D. Factor X
EXPLANATION: Ans: C. Factor VIII
Antidote of warfarin is vitamin k.
Vitamin K dependent clotting factors are IIa VIIa, IX, Xa
Also REMEMBER:
WEPT -Warfarin effects Extrisic Pathway and monitored by PT.
HINT-Heparin effects INtrinsic Pathway and monitored by aPTT.
12. A 40 yr old male had undr gone splenectomy 20 yr ago. Peripheral blood smear examination would show the presence of:
A. Dohle bodies
B. Hypersegmented neutrophils
D. Howell-jolly bodies
C. Spherocytes
EXPLANATION: Ans: D. Howell-jolly bodies
Howell-Jolly bodies are histopathological findings of basophilic nuclear renmants (clusters of DNA) in circulating erythrocytes":
# Howell-jolly bodies are seen in Splenectomy due in trauma
# Asplenia.
# Sickle cell anaemia
# Autosplenectomy
Also REMEMBER
HISTOPATHOLOGICAL CHARACTERISTICS
O Bollinger bodies O Fowl pox
O Russell bodies O Multiple myeloma
* Halberstaedter Prowazeke bodies * Chlamydia trachomatis
O Ditcher bodies o Waldenstorm macroglobulinemia
O Dohle bodies OSevere inflammatory disease or sepsis
O Mason bodies OBronchiolitis obliterans with organizing pneumonia
o Heinz bodies *Glucose-6-phosphate deficiency
* Thalassemia
13. Russel bodies are seen in:
A. Plasma cells
C Neutrophil
B. Esinophills
D. Myeloma cells
EXPLANATION: Ans: A. Plasma cells
Russell bodies are eosinophilic, large homogenous immunoglobulin containin, inclusions usually found in a plasma cell under going excessive synthesis of immunoglobulin, the Russell body is characterstic of the distended endo-plasmic reticulum
*Russel bodies are seen in Multiple myeloma
14. Risk of transmission of HIV in needle prick is:
A. 0.3%
C 3-30%
B. 2-3%
D. 30.%
EXPLANATION: Ans: A. 0.3%
Risk factor of transmission of needle prick injury in
HIV - 0.3%
HCV-2-3%
HBV - 30"
15. Window period of HIV is detected by:
A. Western blot
B. RT-PCR
C. Elisa
D. CD-4 count
EXPLANATION: Ans: B. RT-PCR
# Window Period entry of organism till appearance of antibodies
# IOC in window period of AIDS is RT-PCR.
# Most sensitive test for HIV is ELISA.
# Most specific test for HIV is WESTERN BLOT.
# RT-PCR -Reverse transcription polymerase chain reaction
# ELISA- enzyme-linked immunosorbent assay
# CD4 - cluster of differentiation AND Known As cluster of designation or classification determinant
Test Mneumonic
WESTERN BLOT PROTEINS WEST - PIZZA
SOUTHERN BLOT DNA SOUTH - DOSA
NORTHERN BLOT RNA NORTH - ROTI
ALSO REMEMBER
Opportunistic infections in HIV are as follows-
TB < 400 CD 4 cell count
Toxoplasma <200 CD 4 cell count
Cryptococcus Neoformans < 100 CD 4 cell count
CMV <50 CD 4 cell count
# Cytomegalovirus (CMV)
16. All are seen in nephrotic syndrome EXCEPT:
A. Oedema
B. RBC cast in urine
C. Hypo proteinemia
D. Hyperlipidemia
EXPLANATION: Ans: B. RBC cast in urine
Nephrotic syndrome
# Hypoproteinemia: low molecular weight proteins lost in urine.(<3.5g/24hrs)
# Hypoalbuminemia - <3g/dl) due to disturbed plasma colloid osmotic pressure
# Oedema
# Hyperlipidemia:
↑VLDL (Very-low-density lipoprotein )
↑LDL (low-density lipoprotein )
↑HDL ( (high-density lipoprotein),
# Lipiduria
# Renal vein thrombosis: due to antithrombin III deficiency that leads to increased tendancy to clot.
17. EBV associated with all EXCEPT:
A. Hodgkins
B. Non-Hodgkins
C. Kaposi sarcoma
D. Nasopharyngeal carcinoma
EXPLANATION: Ans: C. Kaposi sarcoma
EBV Associated tumors are- ( EBV -Epstein–Barr virus )
Infectious Mononucleosis
Oral Hairy Leukoplakia
Nasopharyngeal CA
B-Cell Non Hodgkin Lymphoma
Hodgkin Lymphoma
Lymphomas in immuno compromised
Hodgkin's disease — is a cancer of the lymphatic system,
18 Which of the following structure does NOT forms the stomach bed:
A The left kidney
B Hepatic flexure of colon
C The pancreas
D. Transverse mesocolon
ELANATION: Ans: B. Hepatic flexure of colon
@ Structures forming stomach bed are:
Pancreas
Spleen
Left Kidney
Left Suprarenal gland
Transverse colon and its mesocolon
Diaphragm
19 Most common anterior mediastinal tumor is:
A Thymoma
B Cystic lesions
C Neurogenic tumor
D. Bronchogenic cyst
EXPLANATION: Ans: A. Thymoma
# Most common anterior mediastinal tumor is Thymoma.
# Most common lesion associated with pulmonary system is Bronchogenic Cyst.
# Most common middle mediastinal tumor is Cystic lesions.
# Most common Posterior mediastinal tumor is Neurogenic tumor.
20. Coagulative necrosis occur in all EXCEPT:
A Brain
C Heart
B. Liver
D. Kidney
ESPLANATION: Ans: A. Brain
# coagulative necrosis seen almost all organs except Brain.in brain Liquefactive Necrosis is seen" -
