1. Which of the following is known as Guardian of genome?
(1) p53
(2) PTEN
(3) ATM
(4) MDM 2
ANSWER- 1
2. Cells most sensitive to hypoxia are
(1) Myocardial cells
(2) Neurons
(3) Hepatocytes
(4) Renal tubular epithelial cells
ANSWER- 2
3.Fibrosis is due to
(1) TGF-β
(2) IL-7
(3) IL-10
(4) VEGF
ANSWER- 1
4.Leiden factor is
(1) Factor VI
(2) Factor IV
(3) Factor VIII
(4) Factor V
ANSWER- 4
5.Macroglossia is seen in
(1) Amyloidosis
(2) Folic acid deficiency
(3) Iron deficiency
(4) Motor neurone disease
ANSWER- 1
6. Lines of Zahn occur in
(1) Coralline thrombus
(2) Embolus
(3) Infarct
(4) Post Mortem Clot
ANSWER- 1
7. Basement membrane consist of
(1) Type I collagen
(2) Type II collagen
(3) Type III collagen
(4) Type IV collagen
ANSWER- 4
8. Tubercle bacilli in caseous lesions are best demonstrated in
(1) Caseous centre
(2) Margin of necrosis with viable tissue
(3) Epithelioid cells
(4) Langhans' giant cells
ANSWER- 2
9. Transudate differs from exudate in having the following, except:
(1) No inflammatory cells
(2) Low protein content
(3) Low specific gravity
(4) Low glucose content
ANSWER- 4
10. Granuloma is formed by
(1) Neutrophil
(2) Cytotoxic cell
(3) Helper T cell
(4) NK Cells
ANSWER- 3
11. HIV is which type of virus?
(1) Pox virus
(2) Herpes virus
(3) Picorna virus
(4) Retro virus
ANSWER- 4
12. The causative organisms of plague are
(1) Yersinia pestis
(2) Haemophilus ducreyi
(3) Bordetella pertusis
(4) Pseudomonas aeruginosa
ANSWER- 1
13. Malignant cerebral Malaria caused by
(1) P. vivax
(2) P. falciparum
(3) P. ovale
(4) P. malariae
ANSWER- 2
14. Elevation of carcino embryonic antigen (CEA) level is seen in
(1) Liver Cell Cancer
(2) Ovarian Cancer
(3) Breast Cancer
(4) Carcinoma of Colon
ANSWER- 4
15. In Good pasture disease, the antigen is
(1) Basement membrane collagen IV
(2) Bacterial products
(3) Cationic products
(4) DNA
ANSWER- 1
16. Most common paraneoplastic syndrome associated with squamous cell carcinoma of Lung :
(1) Hypercalcemia
(2) Cushing syndrome
(3) Carcinoid syndrome
(4) Hypoglycemia
ANSWER- 1
17. Most common tumour of Heart is
(1) Leiomyosarcoma
(2) Myxoma
(3) Fibroma
(4) Rhabdomyosarcoma
ANSWER- 2
18. Popcorn cell seen in which type of Hodgkin's Lymphoma ?
(1) Nodular Sclerosis type
(2) Mixed Cellularity type
(3) Lymphocyte predominance type
(4) Lymphocyte depletion type
ANSWER-3
19. Chronic gastritis is caused by all, except:
(1) Alcohol
(2) Overuse of salicylates
(3) Helicobacter pylori
(4) Pernicious anaemia
ANSWER- 2
20. Mallory bodies seen in
(1) Primary biliary Cirrhosis
(2) Hepatitis C infection
(3) Post necrotic cirrhosis
(4) Amebic liver abscess
ANSWER- 1
21. Kimmel stiel-Wilson characteristic of:
(1) Diabetic nephropathy
(2) HIV nephropathy
(3) Malignant Hypertension
(4) Renal Cell Carcinoma
ANSWER- 1
22. In 50-80 percent cases of acute appendicitis, the inflammatory lesion initiated by
(1) Bacterial infection
(2) Luminal obstruction
(3) Viral infection
(4) Ischemia
ANSWER- 2
23. Malakoplakia of Urinary bladder is a form of
(1) Dysplasia
(2) Metaplasia
(3) Papillary hyperplasia
(4) Chronic inflammation
ANSWER- 4
24. Heubner arteritis is
(1) Endarteritis Obliterans
(2) Cerebral Syphilitic arteritis
(3) Hypersensitivity vasculitis
(4) Giant cell arteritis
ANSWER- 2
25. Curschmann spirals are seen in
(1) Chronic Bronchitis
(2) Bronchiectasis
(3) Bronchial Asthma
(4) Wegner's Granulomatosi
ANSWER- 3
26. Type of Emphysema associated most often with α-1 antitrypsin deficiency is
(1) Panacinar Emphysema
(2) Distal Emphysema
(3) Centrilobular Emphysema
(4) Irregular Emphysema
ANSWER- 1
27. The most common Lung cancer in women and non-smokers is
(1) Small Cell Carcinoma
(2) Squamous Cell Carcinoma
(3) Adenocarcinor
(4) Large Cell Carcinoma
ANSWER- 3
28. Lichen Planus is characterized by following, except :
(1) Lymphocytic infiltrate at damoepidermal junction
(2) Resolution of Basal layer
(3) Presence of elongated and broad rete ridges
(4) Presence of Civatte bodies
ANSWER- 3
29. Patients of AIDS have the following type of oral leukoplakia:
(1) Speckled
(2) Hairy
(3) Nodular
(4) Wrinkled
ANSWER- 2
30. Bilaterally Symmetrical Contracted Kidney is seen in
(1) Nephrosclerosis
(2) Chronic Pyelonephritis
(3) Chronic Glomerulonephritis
(4) End stage renal disease
ANSWER- 3
31. Cowdry body seen in
(1) Astrocytes
(2) Neuron
(3) Oligodendroglia
(4) Microglia
ANSWER- 2
32. Seminoma is a
(1) Benign tumour
(2) Borderline tumour
(3) Malignant tumour
(4) Locally aggressive tumour
ANSWER- 3
33. Caplan's syndrome may develop in the following types of pneumoconiosis, except:
(1) Berylliosis
(2) Asbestosis
(3) Coal-Worker's pneumoconiosis
(4) Silicosis
ANSWER- 1
34. Crohn's disease is characterised by the following histopathologic features, except
(1) Stricture formation in chronic cases
(2) Widening of submucosa due to oedema
(3) Superficial mucosal ulceration
(4) Non-caseating sarcoid like granulomas
ANSWER- 3
34. Crohn's disease is characterised by the following histopathologic features, except:
(1) Stricture formation in chronic cases
(2) Widening of submucosa due to oedema
(3) Superficial mucosal ulceration
(4) Non-caseating sarcoid like granulomas
ANSWER- 3
35. Marker of level of progressive liver damage in case of hepatitis B is
(1) IgG anti HBs
(2) Anti HCV antibodies
(3) HBV DNA
(4) HBc Antigen
ANSWER- 3
36. Psammoma bodies are found in
(1) Follicular Carcinoma Thyroid
(2) Adenocarcinoma Breast
(3) Adenocarcinoma Stomach
(4) Serous ovarian tumour
ANSWER- 4
37. Paget's Disease has a risk for
(1) Osteoma
(2) Osteosarcoma
(3) Fibrosarcoma
(4) Fibroadenoma
ANSWER- 2
38. Osteoclasts are stimulated by
(1) Calcitonin
(2) Parathyroid hormone (PTH)
(3) Estrogen
(4) Thyroxin
ANSWER- 2
39. The following types of carcinoma of the Breast is characterized by Single file pattern of tumour cells:
(1) Infiltrating duct carcinoma
(2) Invasive lobular carcinoma
(3) Medullary Carcinoma
(4) Tubular Carcinoma
ANSWER- 2
40. BRCA 2 not associated with
(1) Breast cancer
(2) Pancreatic cancer
(3) Ovarian cancer
(4) Vulval cancer
ANSWER- 4
41. Which of the following is post inflammatory pseudotumour of Ear?
(1) Otosclerosis
(2) Cholesteatoma
(3) Chondrodermatitis nodularis
(4) Paraganglioma
ANSWER- 2
42. Molluscum Contagiosum caused by
(1) Human Papilloma Virus
(2) Pox Virus
(3) Herpes Simplex Virus
(4) Ebstein Bar Virus
ANSWER- 2
43. Conn Syndrome is
(1) Chronic hypercortisolism
(2) Secondary hyperaldosteronism
(3) Primary hyperaldosteronism
(4) Adrenogenital Syndrome
ANSWER- 3
44. Strap Cells in histopathology are seen in
(1) Rhabdomyosarcoma
(2) Rhabdomyoma
(3) Histiocytoma
(4) Leiomyosarcoma
ANSWER- 1
45. Sjogren's syndrome produces the following pathological change in the Eуе
(1) Uveitis
(2) Glaucoma
(3) Keratoconjunctivitis
(4) Phthisis bulbi
ANSWER- 3
46. The following tumour is characterized by biphasic pattern of growth
(1) Osteosarcoma
(2) Osteochondroma
(3) Malignant fibrous histiocytoma
(4) Synovial sarcoma
ANSWER- 4
47. In rheumatic fever fibrinoid necrosis occurs in
(1) Collagen
(2) Myocardium
(3) Pericardium
(4) Endocardium
ANSWER- 1
48. Duodenal ulcers are found most commonly at
(1) First part, anterior surface
(2) First part, posterior surface
(3) Second part, anterior surface
(4) Second part, posterior surface
ANSWER- 1
49. Barrett's oesophagus predispose to development of
(1) Reflux oesophagitis
(2) Oesophageal varices
(3) Squamous cell carcinoma
(4) Adenocarcinoma
ANSWER- 4
50.The following type of renal calculi are radiolucent
(1) Calcium phosphate
(2) Uric acid
(3) Magnesium ammonium phosphate
(4) Cystine
ANSWER- 2
51. Lymphatic metastasis of Prostatic carcinoma occur initially to
(1) Obturator lymph node
(2) Perivesical lymph node
(3) Iliac lymph node
(4) Presacral lymph node
ANSWER- 1
52. Krukenberg tumour is bilateral metastatic tumour from the following primary site, except :
(1) Colon
(2) Endometrium
(3) Ovary
(4) Stomach
ANSWER- 2
53. Which is the most frequently altered oncogene in Pancreatic cancer?
(1) K-ras
(2) RB1 (139)
(3) MKK4 (17p)
(4) MYB (69)
ANSWER- 1
54. Herring bone pattern seen in
(1) Fibrosarcoma
(2) Leiomyoma
(3) Osteoma
(4) Osteosarcoma
ANSWER- 1
55. Bullous lesion of the skin is
(1) Lichen Planus
(2) Seborrhoeic dermatitis
(3) Pemphigus Vulgaris
(4) Psoriasis
ANSWER- 3
56. Antoni A and Antoni B growth pattern seen in
(1) Schwannoma
(2) Neurofibroma
(3) Meningioma
(4) Ganglioma
ANSWER- 1